1,461 research outputs found

    Haemostasis and cardiovascular disease

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    The term 'coronary thrombosis' was derived from clinical and pathological observations on myocardial infarction made at least 80 years ago' and perhaps even earlier.'·} It was probably not until the 1930s that clinically manifest ischaemic heart disease in the form of myocardial infarction became a familiar condition rather than the unusual occurrence or even the rarity it had hitherto been. When the growing epidemic of clinical ischaemic heart disease prompted an increasing and concerted research programme after the Second World War, interest largely centred on the lipid nature of the atheromatous plaque and the contributions dietary fat intake and blood cholesterol levels make to it

    Journal of Politeness Research: Introduction

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    This issue marks the 10th year anniversary of the Journal of Politeness Research: Language, behaviour, culture. Ten years ago, founding Editor-in-Chief Christine Christie established the journal as an "international and multidisciplinary forum for research into linguistic and non-linguistic politeness phenomena" (Christie 2005: 1). Under her editorial guidance, the journal published a great number of papers which embodied this founding principle. In 2010, Derek Bousfield and Karen Grainger took over the editorship and in 2013 Karen Grainger became the sole Editor-in-Chief, and the Journal of Politeness Research has grown and matured further under the stewardship of Bousfield and Grainger. Today, with the invaluable contributions of authors and reviewers, and the continuous support of the journal's readership, editorial team and advisory board, the journal remains a flagship for and a pioneer of research into all kinds of politeness phenomena. To celebrate this 10th year anniversary, it is worth reviewing in detail what has been achieved so far, and to take a look at promising future developments of politeness research

    Waar is de beste dokter?

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    Oratie uitgesproken door Prof.dr. J.G. van der Bom bij de aanvaarding van het ambt van hoogleraar in de in de Klinische Epidemiologie in het bijzonder Transfusie Geneeskunde leeropdracht MET hoofdlettersxx aan de Universiteit Leiden op vrijdag 23 januari 2015LUMC / Geneeskund

    Text World Theory and stories of self: a cognitive discursive approach to identity

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    This thesis offers a text-worlds-approach to the study of linguistic identity in discursive interaction. It focuses on how settled Chinese migrants in Sheffield, who migrated predominantly from Hong Kong and the New Territories, construct their identities linguistically. To this extent, linguistic interview data is analysed with the use of the conceptual framework Text World Theory (e.g. Gavins 2007a; Werth 1999). As such, this thesis has three central aims: to extend the use of Text World Theory by applying it to spoken discourse; to examine the ways in which people linguistically represent themselves and talk about their life experiences; and to provide insight into the narratives of Chinese migrants and their families in Sheffield in particular. The linguistic data used in this thesis has been collected through 18 months of ethnographic fieldwork at a Chinese complementary school in Sheffield, UK. Based on the outcome of the analytical investigations of linguistic interview data, I aim to offer several original contributions. Firstly, I hope to provide a better understanding of migrant lives, by investigating the narrated experiences of Chinese migrants and their families. Secondly, I offer Text World Theory as a suitable framework for the study of linguistic identity. I extend the framework to the relatively unexplored domain of spoken discourse, synthesising a discursive approach to identity (e.g. Bucholtz and Hall 2005) with a Text World Theory approach (e.g. Gavins 2007a; Werth 1999). I demonstrate that Text World Theory can explain the complex and multi-layered nature of identity through the scope it provides for tracing linguistic self-representation across multiple worlds. Finally, I show that the framework is particularly adept at synthesising macro-level analysis of discursive interaction with detailed micro-level analysis of linguistic choices and their conceptual consequences

    A reader response method not just for ‘you’

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    This article contributes to empirical literary studies by offering a new reader response method for examining targeted textual features. With the aim of further establishing the new paradigm of reader response research in stylistics, we utilise a Likert scale – a tool that is usually used to generate data that is analysed quantitatively – to elicit qualitative data and, crucially, show how that data can be synthesised with an analysis of the primary text to provide empirically based conclusions relevant to particular textual features for cognitive narratology and stylistics. While we offer a new method that can be used to investigate textual features in all kinds of text, we exemplify our approach via the investigation of second-person narration in geniwate and Larsen’s digital fiction The Princess Murderer and provide a new understanding of the experiential nature of ambiguous forms of ‘you’ in fiction. Our stylistic analyses show how responses can be generated by linguistic features in the text. We then analyse reader responses to those examples and show that this can provide a more nuanced account of ‘you’ narratives than a stylistic analysis alone because it affords insight into how different readers do or do not psychologically project into and/or assume the role of ‘you’. Our results represent the first time that current typologies of the second person have been empirically tested and we are the first study to find an empirical basis for doubly deictic ‘you’. We therefore contribute a new empirically based understanding of how readers experience ambiguous forms of ‘you’ in fiction

    Immersion in digital fiction

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    In this article, we profile an empirically grounded, cognitive approach to immersion in digital fiction by combining text-driven stylistic analysis with insights from theories of cognition and reader-response research. We offer a new analytical method for immersive features in digital fiction by developing deictic shift theory for the affordances of digital media. We also provide empirically substantiated insights to show how immersion is experienced cognitively by using Andy Campbell and Judi Alston’s (2015) digital fiction piece WALLPAPER as a case study. We add ‘interactional deixis’ and ‘audible deixis’ to Stockwell’s (2002) model to account for the multimodal nature of immersion in digital fiction. We also show how extra-textual features can contribute to immersion and thus propose that they should be accounted for when analysing immersion across media. We conclude that the analytical framework and reader response protocol that we develop here can be adapted for application to texts across media

    Risk Factors for Alloimmunisation after red blood Cell Transfusions (R-FACT): a case cohort study

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    INTRODUCTION: Individuals exposed to red blood cell alloantigens through transfusion, pregnancy or transplantation may produce antibodies against the alloantigens. Alloantibodies can pose serious clinical problems such as delayed haemolytic reactions and logistic problems, for example, to obtain timely and properly matched transfusion blood for patients in which new alloantibodies are detected. OBJECTIVE: The authors hypothesise that the particular clinical conditions (eg, used medication, concomitant infection, cellular immunity) during which transfusions are given may contribute to the risk of immunisation. The aim of this research was to examine the association between clinical, environmental and genetic characteristics of the recipient of erythrocyte transfusions and the risk against erythrocyte alloimmunisation during that transfusion episode. METHODS AND ANALYSIS STUDY DESIGN: Incident case-cohort study. SETTING: Secondary care, nationwide study (within the Netherlands) including seven hospitals, from January 2005 to December 2011. STUDY POPULATION: Consecutive red cell transfused patients at the study centres. INCLUSION: The study cohort comprises of consecutive red blood cell transfused patients at the study centre. EXCLUSION: Patients with transfusions before the study period and/or pre-existing alloantibodies.Cases defined as first time alloantibody formers; Controls defined as transfused individuals matched (on number of transfusions) to cases and have not formed an alloantibody. STATISTICAL ANALYSIS: Logistic regression models will be used to assess the association between the risk to develop antibodies and potential risk factors, adjusted for other risk factors. ETHICS AND DISSEMINATION: Approval at each local ethics regulatory committee will be obtained. Data will be coded for privacy reasons. Patients will be sent a letter and an information brochure explaining the purpose of the study. A consent form in presence of the study coordinator will be signed before the blood taking commences. Investigators will submit progress summary of the study to study sponsor regularly. Investigators will notify the accredited ethics board of the end of the study within a period of 8 weeks.Stemcel biology/Regenerative medicine (incl. bloodtransfusion
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